Experimentelle Untersuchungen Von Knochentransplantaten Mit Unveranderter Und Mit Denaturierter Knochengrundsubstanz by Leonhard Schweiberer

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Experimentelle Untersuchungen Von Knochentransplantaten Mit Unveranderter Und Mit Denaturierter Knochengrundsubstanz


Experimentelle Untersuchungen Von Knochentransplantaten Mit Unveranderter Und Mit Denaturierter Knochengrundsubstanz Leonhard Schweiberer

Published January 1st 1970

ISBN : 9783662237113

Paperback

70 pages


Seit 1957 wird nach langjahrigen wissenschaftlichen Vorarbeiten durch Maatz und Bauermeister ein industriell zubereiteter, macerierter Rinderknochen dem chirurgisch tatigen Kliniker als Knochentransplan tat angeboten. Der sog. "Kieler Span" wird durch ein besonderes Macera tionsverfahren entfettet und seiner cellularen Bestandteile entledigt. Seine biologische Struktur und die verbliebenen Kalksalze sollen ihn be fahigen - in ein geeignetes knochernes Lager verpflanzt - metaplasti sche Knochenneubildung in Gang zu setzen oder das Lager zur Callus bildung anzuregen. Der Wunsch des Klinikers nach einem geeigneten Knochentrans plantat, das die autologe Knochentransplantation ersetzt, ist verstand lich. Die autologe Transplantation erfordert einen zweiten operativen Eingriff, fur grosse knochenplastische Eingriffe steht nicht immer ge nugend korpereigener Knochen zur Verfugung. Dem heteroplastischen Material dagegen sind bezuglich Gewinnung, Menge und Form keine Grenzen gesetzt. Die Maceration des tierischen Knochengewebes beseitigt die be kannten Nachteile der Antigen-Antikorperreaktion art-und individual spezifischer Eiweisskorper. Experimentelle Ergebnisse und klinische An fangserfolge weckten die Hoffnung auf volle klinische Verwendbarkeit des Spanes. Seither sind mehr als 10 Jahre klinischer Erprobung vergangen. Die Angaben uber den klinischen Wert des Macerationsspanes sind wider spruchlich. Es erschien deshalb zweckmassig, experimentell Leistungs fahigkeit und Grenzen des Spanes zu prufen und die Ergebnisse in Be ziehung zu setzen zu den bekannten Gesetzmassigkeiten der Knochen uberpflanzung. Der Wert eines Transplantates wird gemessen I. am Ablauf des unmittelbaren Einheilungsvorganges, 2. an seiner Osteogenetischen Potenz, 3. an der Art des knochernen Umb


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Leonhard Schweiberer

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